ELISA POLI anti-
Quantity:100µg
Purification:Immunogen affinity purified
Form:liquid
Purity:?95% as determined by SDS-PAGE
Host:Rabbit
Clonality:polyclonal
Clone ID:
Isotype:IgG
Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background:Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobµLin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
Immunogen:polymerase(DNA directed) iota
Synonyms:DNA polymerase iota, Eta2, POLI, polymerase (DNA directed) iota, RAD30 homolog B, RAD30B, RAD3OB
Observed MW:87 kDa
Uniprot ID:Q9UNA4
Reactivity:, Mouse, Rat
Tested Application:ELISA, WB, IHC, IP
Recommended dilution:WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:20-1:200
Gene ID:11201
Research Area:Metabolism
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