ELISA POLI Antibody, FITC

Quantity :50µg Clone Number: Aliases:DNA polymerase iota antibody; Eta 2 antibody; Eta2 antibody; POLI antibody; POLI_ antibody; Polymerase (DNA directed) iota antibody; RAD 30B antibody; RAD30 homolog B antibody; RAD30, S. cerevisiae, homolog of antibody; RAD30B antibody; RAD3OB antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9UNA4 Immunogen:Recombinant DNA polymerase iota protein (458-711AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobµLin genes. Forms a Schiff base with 5\'-deoxyribose phosphate at abasic sites, but may not have lyase activity. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:POLI Research Areas:Epigenetics and Nuclear Signaling