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ELISA Gabra3 anti-

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Quantity :100µL Clone Number: Aliases:Gabra3 antibody; Gabra-3 antibody; Gamma-aminobutyric acid receptor subunit alpha-3 antibody; GABA(A) receptor subunit alpha-3 antibody Product Type:Polyclonal Antibody Immunogen Species:Rattus norvegicus (Rat) UniProt ID:P20236 Immunogen:Peptide sequence around aa. 33~37(R-R-Q-E-P)derived from Rat GABA A Receptor a3. Raised in:Rabbit Reactivity:, Rat, Mouse Tested Applications:ELISA, WB; WB:1:500-1:1000 Background:GABA (g-aminobutyric acid) is the primary inhibitory neurotransmitter in the central nervous system and interacts with three different receptors: GABA(A), GABA(B) and GABA(C) receptor. The ionotropic GABA(A) and GABA(C) receptors are ligand-gated ion channels that produce fast inhibitory synaptic transmission. In contrast, the metabotropic GABA(B) receptor is coupled to G proteins that modµLate slow inhibitory synaptic transmission (1). Functional GABA(B) receptors form heterodimers of GABA(B)R1 and GABA(B)R2 where GABA(B)R1 binds the ligand and GABA(B)R2 is the primary G protein contact site (2). Two isoforms of GABA(B)R1 have been cloned: GABA(B)R1a is a 130 kD protein and GABA(B)R1b is a 95 kD protein (3). G proteins subsequently inhibit adenyl cylase activity and modµLate inositol phospholipid hydrolysis. GABA(B) receptors have both pre- and postsynaptic inhibitions: presynaptic GABA(B) receptors inhibit neurotransmitter release throµgh suppression of high threshold calcium channels, while postsynaptic GABA(B) receptors inhibit throµgh coupled activation of inwardly rectifying potassium channels. In addition to synaptic inhibition, GABA(B) receptors may also be involved in hippocampal long-term potentiation, slow wave sleep and muscle relaxation (1). Jones, K.A. et al. (2000) Neuropsychopharmacology 23, S41-9. Duthey, B. et al. (2002) J Biol Chem 277, 3236-41. Kaupmann, K. et al. (1997) Nature 386, 239-46. Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:Gabra3 Research Areas:Neuroscience

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