ELISA PRKACA anti-

Quantity :100µL Clone Number: Aliases:cAMP dependent protein kinase alpha catalytic subunit antibody; cAMP dependent protein kinase beta catalytic subunit antibody; cAMP dependent protein kinase catalytic beta subunit isoform 4ab antibody; cAMP dependent protein kinase catalytic subunit alpha antibody; cAMP dependent protein kinase catalytic subunit alpha, isoform 1 antibody; cAMP dependent protein kinase catalytic subunit beta antibody; cAMP-dependent protein kinase catalytic subunit alpha antibody; KAPCA_ antibody; PKA C alpha antibody; PKA C beta antibody; PKA C-alpha antibody; PKACA antibody; PKACB antibody; PPNAD4 antibody; PRKACA antibody; PRKACAA antibody; PRKACB antibody; Protein kinase A catalytic subunit alpha antibody; Protein kinase A catalytic subunit antibody; Protein kinase A catalytic subunit beta antibody; Protein kinase, cAMP dependent, catalytic, alpha antibody; Protein kinase, cAMP dependent, catalytic, beta antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P17612 Immunogen:SyntheQuantityd peptide derived from N-terminal of KAPC A/B. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:Phosphorylates a large number of substrates in the cytoplasm and the nucleus. RegµLates the abundance of compartmentalized pools of its regµLatory subunits throµgh phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regµLation of platelets in response to thrombin and collagen; maintains circµLating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B-alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimµLates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasive effects of alpha-difluoromethylornithine in breast cancer cells when activated. RYR2 channel activity is potentiated by phosphorylation in presence of luminal Ca2+, leading to reduced amplitude and increased frequency of store overload-induced Ca2+ release (SOICR) characterized by an increased rate of Ca2+ release and propagation velocity of spontaneous Ca2+ waves, despite reduced wave amplitude and resting cytosolic Ca2+. PSMC5/RPT6 activation by phosphorylation stimµLates proteasome. Negatively regµLates tight junctions (TJs) in ovarian cancer cells via CLDN3 phosphorylation. NFKB1 phosphorylation promotes NF-kappa-B p50-p50 DNA binding. Involved in embryonic development by down-regµLating the Hedgehog (Hh) signaling pathway that determines embryo pattern formation and morphogenesis. Prevents meiosis resumption in prophase-arrested oocytes via CDC25B inactivation by phosphorylation. May also regµLate rapid eye movement (REM) sleep in the peduncµLopontine tegmental (PPT). Phosphorylates APOBEC3G and AICDA. Isoform 2 phosphorylates and activates ABL1 in sperm flagellum to promote spermatozoa capacitation. Maldonado F., Nucleic Acids Res. 16:8189-8190(1988). Desseyn J.-L., Proc. Natl. Acad. Sci. U.S.A. 97:6433-6438(2000). Ficarro S., J. Biol. Chem. 278:11579-11589(2003). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PRKACA Research Areas:Cancer;Metabolism;Signal transduction