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ELISA Grin2b anti-

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Quantity :100µL Clone Number: Aliases:Grin2bGlutamate receptor ionotropic antibody; NMDA 2B antibody; GluN2B antibody; Glutamate [NMDA] receptor subunit epsilon-2 antibody; N-methyl D-aspartate receptor subtype 2B antibody; NMDAR2B antibody; NR2B antibody Product Type:Polyclonal Antibody Immunogen Species:Rattus norvegicus (Rat) UniProt ID:Q00960 Immunogen:Peptide sequence around aa.1250-1254(N-L-Y-D-I) derived from NMDANR2B Subunit. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:1000 Background:NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx throµgh them, resµLting in an irreversible neuronal death Kornau H.C., Schenker L.T., Kennedy M.B., Seeburg P.H.Science 269:1737-1740(1995) Kurschner C., Mermelstein P.G., Holden W.T., Surmeier D.J.Mol. Cell. Neurosci. 11:161-172(1998) Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:Grin2b Research Areas:Neuroscience

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