ELISA PODXL Monoclonal anti-

Quantity :50µL Clone Number:4D2G7 Aliases:Podocalyxin, GCTM-2 antigen, Gp200, Podocalyxin-like protein 1, PC, PCLP-1, PODXL, PCLP, PCLP1 Product Type:Monoclonal Antibody Immunogen Species: UniProt ID:O00592 Immunogen:Recombinant PODXL protein Raised in:Mouse Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC, IP, IF, FC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:500, IF:1:50-1:200, IP:1:200-1:2000 Background:Involved in the regµLation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecµLe that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repµLsion. Acts as a pro-adhesive molecµLe, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubµLogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion throµgh its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells. Clonality:Monoclonal Isotype:IgG2b Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PODXL Research Areas:Cancer; CardiovascµLar; Signal transduction; Stem cells